titin chemical full name the lifesaver molecule that holds the body together - iimu.edu.in
With its length of ~27,000 to ~35,000 amino acids (depending on the splice isoform), titin is the largest known protein. [14] Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene, [15] as well as the longest single exon (17,106 bp).
With its length of ~27,000 to ~35,000 amino acids (depending on the splice isoform), titin is the largest known protein. [14] Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene, [15] as well as the longest single exon (17,106 bp).
Titin is an exceptionally large protein that has a critical role in both the structure and function of striated muscle tissues, which encompasses both cardiac and skeletal muscles. Titin is one of the largest known proteins, with a molecular weight that can exceed 3000 kDa.
Encoded by the TTN (titin gene), titin has emerged as a major disease locus for cardiac disorders. Functionally, titin acts as a third myofilament type, connecting sarcomeric Z-disks and M-bands, and regulating myocardial passive stiffness and stretch sensing.
Titin is a protein of immense scale found exclusively in the striated muscle tissue of vertebrates, including the heart and skeletal muscles. It holds the distinction of being the largest known protein in nature, performing a foundational role in muscle structure and mechanics.
In this minireview, we first provide general information on the structure and function of the giant muscle protein titin (also known as connectin) and then focus on the dynamic role of titin as an important regulatory node in the sarcomeric cytoskeleton.
With a molecular weight of ∼3–4 MDa (in humans), titin is the largest protein expressed in mammals, extending from the Z-disk to the M-band where the N- and C-termini are anchored, respectively. Titin is divided into four portions based on the orientation of the molecule within the half sarcomere.
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.